Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation
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Azelaic acid stimulates catalase activation and promotes hair growth through upregulation of Gli1 and Gli2 mRNA and Shh protein
Objective: Although azelaic acid is effective for treatment of acne and rosacea, the biological activity of azelaic acid and the effect of its combination therapy with minoxidil were not elucidated with regard to hair growth. Materials and Methods: In this study, mouse vibrissae follicles were dissected on day 10 after depilation. Then, the bulb and bulge...
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The effects of seasons on lipid and fatty acid profiles of muscle types (mantle and arm) of Mediterranean octopuses (common octopus-Octopus vulgaris and musky octopus-Eledone moschata) were investigated. The results showed that lipid levels ranged from 0.75% to 1.60% in both muscle types of octopuses which were considered as lean. Lipid levels in mantle tissues of both octopus species were hig...
متن کاملSeasonal Variations of Fat and Fatty Acid Composition in Muscle Tissues of Mediterranean Octopuses
The effects of seasons on lipid and fatty acid profiles of muscle types (mantle and arm) of Mediterranean octopuses (common octopus-Octopus vulgaris and musky octopus-Eledone moschata) were investigated. The results showed that lipid levels ranged from 0.75% to 1.60% in both muscle types of octopuses which were considered as lean. Lipid levels in mantle tissues of both octopus species w...
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Emerging evidence documents a key function for the forkhead transcription factor FoxO1 in cellular metabolism. Here, we investigate the role of FoxO1 in the regulation of fatty acid (FA) metabolism in muscle cells. C2C12 cells expressing an inducible construct with either wild type FoxO1 or a mutant form (FoxO1/TSS) refractory to the protein kinase B inhibitory effects were generated. FoxO1 act...
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Interleukin (IL)-6 is chronically elevated in type 2 diabetes but also during exercise. However, the exact metabolic role, and hence the physiological significance, has not been elucidated. The objective of this study was to investigate the in vivo effect of recombinant human (rh) IL-6 on human fat and glucose metabolism and signaling of both adipose tissue and skeletal muscle. Eight healthy po...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2020
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.2019103304